Genome-wide characterization of host-pathogen interactions

Microbial pathogenesis studies often focus on the pathogen. The other half of the story is the host. There are many molecular interactions that manifest as symptoms of disease. Identifying which host genes are required for a pathogen to establish and maintain an infection at the cellular level can generate a complete view of cellular pathogenesis. With the whole picture, new or re-purposed host-targeted therapeutics that interfere with these interactions can be developed as treatments. I will share how my group has used CRISPR technologies to investigate host-viral, -bacterial, and -toxin mechanisms of disease. Our preliminary work combining CRISPR studies, organoid, and organ-on-a-chip technologies with our Hummino human immune mutation diversity panels will also be discussed. Through this work our group has increased the understanding of disease pathogenesis while identifying new targets to prevent or treat infections.

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